Endocrine Abstracts

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.Methods: Thir...

Endocan has been suggested as a marker for endothelial dysfunction. Some evidence exists that Graves’ disease may be associated with impaired endothelial function. The aim of the study was to evaluate serum endocan, endothelial growth factor (VEGF) and carotid intima media thickness (CIMT) in patients with Graves’ disease. Thirty one newly diagnosed patients with Graves’ disease and 31 healthy volunteers with similar age and sex were examined. Serum endocan, VEG...

Idiopathic granulomatous hypophysitis is a very rare inflammatory disease of the pituitary gland. Primary hypophysitis represents a difficult diagnostic challenge because it can imitate pituitary adenomas clinically and radiologically. The diagnosis is usually made histologically by hypophysectomy. We herein present a rare case of idiopathic granulomatous hypopysitis diagnosed primarily by pituitary biopsy.Case: A 50-year-old female patient presented wit...

Cardiovascular deleterious effects of short term hypothyroidism are not well known. We aimed to investigate proprotein convertase subtilisin/kexin type 9 (PCSK9), soluble lectin-like oxidized LDL receptor 1 (sLOX-1) and ankle brachial index (ABI) in patients with thyroid cancer with short term overt hypothyroidism due to thyroid hormone withdrawal (THW). Twenty-one patients who require radioactive iodine (RAI) ablation or RAI scan and thirty-six age, sex, BMI similar euthyroid...

Introduction: Infliximab is a tumour necrosis factor (TNF) α inhibitor and used for the treatment of psoriasis. Herein, we report a case of destructive thyroiditis accompanied by transient thyrotoxicosis resulting from the infliximab therapy for the treatment of psoriasis.Case report: A 57-year-old man suffered from psoriasis and was treated with infliximab therapy for 4 years. Thyroid function tests were normal before infliximab therapy. When the p...

Introduction: Hypoglycemia is a complication of diabetes mellitus (DM) with high morbidity and mortality. Risk of hypoglycemia is affected by the type and duration of DM, use of insulin or oral antidiabetic agents, dietary habits and comorbidities. In this study, we aimed to understand frequency and causes of hypoglycemia in patients with type 2 DM in Turkish population and especially collect data about hypoglycemia in geriatric population.Methods: Betwe...

Objective: In differentiated thyroid carcinoma (DTC), TSH suppression with levothyroxine (L-T4) is a standard treatment for reducing tumor recurrence after total thyroidectomy. This study aims to evaluate the effect of long-term TSH suppression on the development of sarcopenia and frailty in elderly patients with DTC.Method: Seventy patients aged 60 years and older with stable TSH levels during the last year and under L-T4 due to DTC were included in the...

Dipeptidyl peptidase 4 (DPP-4) is thought to play a role in the pathophysiology of metabolic and inflammatory diseases. Increased ADA activity has been suggested to induce insulin resistance and inflammation. We investigated DPP-4 and ADA activities, serum nitric oxide (NO) level and nitric oxide synthase (NOS) activity which are the oxidative stress parameters in patients with PCOS. Fifty two women with PCOS and 41 healthy women were included in this study. Serum ADA activity...

Introduction: Oncogenic osteomalasia is a rare paraneoplastic syndrome in which a tumor produces fibroblast growth factor 23 which leads to increased urinary phosphate excretion resulting in hypophosphatemia. It is frequently associated with mesenchymal tumors of bone and soft tissues. We report a case of oncogenic osteomalasia due to lipoma.Case report: A 38-year-old female patient with a 6-year history of left hip pain which progressively worsened over...

Background: Adrenal venous sampling (AVS) is the gold standard diagnostic approach for differentiating unilateral from bilateral primary aldosteronism (PA). However, it is a costly, invasive, and operator-dependent procedure with restricted availability.Objectives: It was aimed to develop a prediction model based on a simple clinical score with prominent parameters from the current literature for the subtype diagnosis of PA. The contribution of adrenal v...